There is a probable link between disinhibition and serotonergic neurotransmission disruption in bvFTD patients, which showed a marked decrease in serotonin 5HT1A and 5-HT2A receptor-binding potential.50,51 This is the theoretical basis for antidepressant response in this form of dementia, especially SSRIs. The gene discussed is HTR1A; the disease is behavioral variant of frontotemporal dementia.