Around 40–50% of FTD cases present a positive family history, with 10% showing an autosomal dominant pattern.7 The most common monogenetic inheritance occur in microtubule-associated protein tau (MAPT), chromosome 9 open reading frame 72 (C9ORF72), and progranulin (GRN) genes, representing 25% of FTD cases.8 The gene discussed is GRN; the disease is frontotemporal dementia.