Sesamin attenuates lipopolysaccharide-induced acute lung injury via inhibition of the TLR4 signaling pathway [64], enhances Nrf2-mediated protective defense against oxidative stress and inflammation in colitis by activating AKT and ERK [75], protects against renal I/R injury by promoting the CD39-adenosine-A2AR signal pathway [7], inhibits CCl4-induced oxidative stress-mediated apoptosis in mice via the JNK pathway [60], and ameliorates myocardial I/R injuries through activation of the Akt/eNOS signaling pathway [8]. The gene discussed is TLR4; the disease is colitis.