IL18 and osteoarthritis: In line with our results, curcumin was also found to suppress the levels of proinflammatory mediators including IL-1β, IL-18, interferon gamma (IFN-γ), and TNF-α in a THP-1 macrophage cell line via the downregulation of NLRP3 inflammasome activation in a mouse medial meniscus model of osteoarthritis [41].