Recent studies indicate that cell ferroptosis sensitivity is regulated by the extrinsic or transporter-dependent pathway and the intrinsic or enzyme-regulated pathway (SLC7A11/GPX4, NADPH/FSP1/CoQ10, and GCH1/BH4), and the sensitivity of lung cells to ferroptosis is closely related to the progression of lung diseases. Here, AIFM2 is linked to lung disorder.