In the studies of COVID-19, acute lung injury (ALI), pulmonary fibrosis (PF), COPD, lung cancer, and other lung diseases; unstable iron accumulation; and enhanced lipid peroxidation (LPO) are observed in lung cells, accompanied by the downregulation of glutathione peroxidase 4 (GPX4), suggesting that ferroptosis in lung tissue plays a vital role in various lung diseases [8–11]. Here, GPX4 is linked to lung cancer.