In this study, by observing the effect of electroacupuncture (EA) on the production of inflammatory factors such as IL-1β, TNF-α, and IL-6 in rats with cognitive impairment in CHE, we explored the role of TLR4/MyD88/NF-κB and p38MAPK/STAT3 signaling pathways in improving CHE-related cognitive impairment in rats undergoing EA, as well as the underlying mechanism and therapeutic targets. This evidence concerns the gene STAT3 and Cognitive impairment.