The expression of TNF family genes in the two TNF clusters is shown in Figure 1(d), among which 19 TNF family genes (TNFRSF6B, CD70, TNFSF9, TNFRSF14, TNFRSF25, RELT, TNFRSF18, TNFRSF4, FASLG, CD40LG, TNFSF8, LTB, TNFSF18, EDA, EDA2R, CD40, TNFRSF12 A, LTBR, and TNFSF15) were significantly correlated with the clinical characteristics (M, N, T, stage, grade, gender, and age) of PAAD patients. The gene discussed is TNFRSF4; the disease is pancreatic adenocarcinoma.