U2AF1 and acute myeloid leukemia: Wang E. et al. (2019) revealed 21 RBP candidates upregulated in AML that are critical for maintaining RNA splicing and survival of AML. Mutations in RPS14, SRBP2, SF3B1, and U2AF1 can lead to myelodysplastic abnormalities, hematopoietic dysfunction, AML, and other blood-related diseases (Ebert et al., 2008; Komeno et al., 2015; Shirai et al., 2015; Mortera-Blanco et al., 2017; de Rooij et al., 2019).