KCNQ1 and cholangiocarcinoma: It has been shown in previous work to function as a cis-silencer of the imprinted KCNQ1 cluster and to be involved in the metastasis and proliferation of various tumors, such as hepatocellular carcinoma, cholangiocarcinoma, ovarian and breast cancer tumors (Feng et al., 2018; Luo and Jin, 2019).