HOTAIR to be implicated in cancer metastasis regulation by targeting the chromatin repressor polycomb protein (Gupta et al., 2010), and linc00673 to activate WNT/β-catenin signaling and aggravate lung adenocarcinoma by binding between casein kinase 1ε (CK1ε) and DEAD box RNA helicase DDX3 (Guan et al., 2019). Here, HOTAIR is linked to lung adenocarcinoma.