HELLS and cancer: A GeneCards (www.genecards.org) (Stelzer et al., 2016) analysis showed these gene products to be involved in some cancer-related pathways, for instance TRAF5 in the RANKL/RANK (receptor activator of NFKB (ligand)) signaling pathway, COL7A1 in ERK signaling, HELLS in the AMPK enzyme complex pathway and BRCA1 pathway, ARHGEF19 in RET signaling, and GGCT in a cancer metabolism pathway.