Based on the results, we observed no significant causal link between risk of RA and circulating adiponectin levels (β: 0.007, 95% CI: –0.003 to 0.018, p = 0.177) using the IVW method (Supplementary Figure 1), MR-Egger regression (β: 0.011, 95% CI: –0.007 to 0.029, p = 0.199), weighted-median method (β:–0.003, 95% CI: –0.018 to 0.013, p = 0.708), and MR PRESSO (β: 0.007, 95% CI: –0.003 to 0.018, p = 0.188) (Figure 2D). The gene discussed is ADIPOQ; the disease is rheumatoid arthritis.