Meanwhile, the CCK8 assay also confirmed that the proliferation of HCT-8 increased after the hnRNPA2B1 overexpression, and the effects of hnRNPA2B1 were blocked after inhibiting the MAPK signaling (Figure 4E), which further supported that hnRNPA2B1 promotes colon cancer progression via the MAPK pathway. Here, HNRNPA2B1 is linked to malignant colon neoplasm.