In conclusion, the present work is the first to show the expression, function and putative mechanism of hnRNPA2B1 with respect to cell proliferation and apoptosis in the setting of colon cancer and to propose that the ERK/MAPK pathway is activated by hnRNPA2B1 during this development process. The gene discussed is HNRNPA2B1; the disease is malignant colon neoplasm.