In terms of alternative splicing, our results in PPI and GO analyses both show that the alternative splicing under the condition of high expression of hnRNPA2B1 the regulation of excision is enhanced, and the process of tumor occurrence and development is also closely related to the post-transcriptional modification of alternative splicing, which means that the alternative splicing function in hnRNPA2B1 may play an important role in the progression of colon cancer, but it still need further experimental proof. Here, HNRNPA2B1 is linked to malignant colon neoplasm.