In the present study, we compared expression of hnRNPA2B1 in colon cancer and matched adjacent normal tissues from databases and clinical samples and found that hnRNPA2B1 was upregulated in colon cancer, which markedly promoted colon cancer cell proliferation in vitro and in vivo. By performing RNA-seq analyses, we observed that activation of ERK/MAPK pathway was strongly associated with expression of hnRNPA2B1. The gene discussed is HNRNPA2B1; the disease is colonic neoplasm.