Table 3 provides and overview of OIT studies (249–279) informing about the number of participants, the study design, clinical and immunological outcomes, side effects and references and/or trial registration numbers which allow to track the studies in the Clinical Trials data base (https://clinicaltrials.gov/). Most of the studies were conducted for peanut allergy whereas OIT studies for tree nut allergies are scarce (Table 3). A study by Andorf et al. (280) is one of the few studies providing evidence for effects of OIT to several different nuts when OIT was combined with anti-IgE treatment. This evidence concerns the gene IGHE and peanut allergic reaction.