Univariate analysis suggested that, compared with the other cancer hallmarks such as PI3K/AKT/mTOR signaling, apoptosis, EMT, G2M checkpoint, TGF-beta signaling, angiogenesis, and hypoxia, glycolysis and immune response were the most significant risk factors affecting the survival of UM patients (Figure 2A). This evidence concerns the gene AKT1 and cancer.