PRTN3 and anti-neutrophil cytoplasmic antibody-associated vasculitis: Pathogenic ANCAs, in particular proteinase 3 (PR3-ANCA) and myeloperoxidase (MPO-ANCA), trigger a deleterious immune response resulting in a pauci-immune necrotizing and crescentic GN, a common manifestation of glomerular injury in AAV (11).