TGFB1 and familial dilated cardiomyopathy: 1CD4+LAP+ Tregs in the peripheral blood of DCM patients were dysfunctional. Their abilities in inhibiting B-cell proliferation and antibody production were impaired (107).2 Bregs induced the expansion of Tregs, and Tregs also increased the number of Bregs in turn (108).3 B cells induced the production of Tregs (109, 110).