Furthermore, PD-L1 expression was increased in tumor cells from Ythdf1−/− tumor-bearing mice, anti-PDL1-treated on Ythdf1−/− tumor-bearing mice made tumor disappeared, the simultaneous depletion of PD-L1 and YTHDF1 was beneficial to the improvement of tumor immune microenvironment (76). This evidence concerns the gene CD274 and neoplasm.