THRB and diabetes mellitus: We tested all the clinical and demographic variables available on the TCGA, and we found that IG richness and diversity were nominally significantly higher in females (p = 0.038 for IGK expression) and heavy smokers [p = 0.015, p = 0.062, and p = 0.041 (IGH, IGK, and IGL entropy) and p = 0.048, p = 0.031, and p = 0.031 (IGH, IGK, and IGL expression)] (Figures 5A, B) while TCR richness and diversity were associated with a history of diabetes [p = 0.031 and p = 0.0063 (TRA and TRB expression) and p = 0.026 and p = 0.018 (TRA and TRB entropy)] (Figure 5B).