Although a significant change in the expression of Cdh1 (E-cadherin) was caused by KNT-127, considering that E-cadherin has a protective role in colitis (32), the decrease in Cdh1 mRNA expression observed in KNT-127-treated mice was probably not the cause of the relief but reflected the reduction in inflammation (Figures 3A–C). Here, CDH1 is linked to colitis.