Interestingly, a high expression of CD1d has been associated with a poor prognosis in leukemia (149–152), but it should be noted that Vδ3 cells can expand and respond against CD1d+ target cells through a CD1d-restricted reactivity and with a potent secretion of effector molecules, such as IFN-γ (60, 153). Here, IFNG is linked to leukemia.