These changes can also be observed in leukemia, as γδ T cells increase the expression of PD1, CTLA4 and BTLA, while LCs strongly regulate the expression of their ligands, such as PD-L1, CD80 and/or CD86, and herpesvirus-entry mediator (HVEM), respectively (212). The gene discussed is TNFRSF14; the disease is leukemia.