AIFM1 and acute kidney injury: Additionally, lncRNA TCONS_00016233 was observed to aggravate septic AKI via the modulation of the miR-22-3p/apoptosis-inducing factor mitochondrion-associated 1 axis, which indicated that TCONS_00016233 not only acted as a diagnostic marker but also as a new target for sepsis-induced AKI therapy (87).