Interestingly, CRNDE could sponge miR-181a-5p, eventually promoting the expression of NF-kB, and aggravated the kidney injury induced by sepsis (32), while downregulated LncRNA CRNDE was reported to increase miR-181a-5p and reduce PPARα by Wang et al., thereby aggravating inflammation in sepsis (61). This evidence concerns the gene PPARA and Sepsis.