To better elucidate the mechanism of the CD27-CD70 pathway and its impact on GVHD pathogenesis, cytokines associated with GVHD were measured in CD70 knockout host mice which showed significantly higher levels of pro-inflammatory IFNγ, TNFα, IL-2, and IL-17 when compared to WT mice (see Figure 3) (35). This evidence concerns the gene IL2 and graft versus host disease.