CD27 Expressing B-cell Malignancies (Hodgkin’s Lymphoma, Chronic Lymphocytic Leukemia, Mantle Cell Lymphoma, Marginal Zone B Cell Lymphoma, Any T-cell Malignancy, Solid Tumors (Metastatic Melanoma, Renal (Clear) Cell Carcinoma, Hormone-refractory Prostate Adenocarcinoma, Ovarian Cancer, Colorectal Adenocarcinoma, Non-small Cell Lung Cancer), Burkett’s Lymphoma, Primary Lymphoma of the Central Nervous System. The gene discussed is CD27; the disease is primary central nervous system lymphoma.