For example, haplotype analysis revealed three founder mutations (BRCA1 c.68_69delAG, c.5266dupC, and BRCA2 c.5946delT) in the Ashkenazi Jewish population, and a recurrent F8 mutation (c.6046C>T) causing hemophilia A in a northern Italian population (43, 44). This evidence concerns the gene BRCA2 and hemophilia A.