Indeed, it was observed that infection with M. smeg had higher levels of TNFa and iNOS2, which is indicative of a pro-inflammatory Th1 response in the context of the infected macrophages while infection with M. tb exhibited a higher IL-10 and Arg1 levels, which is indicative of a Th2 or anti-inflammatory response in the context of the macrophages (Supplementary Figure 4). This evidence concerns the gene TNF and infection.