A well characterized recombinant fragment of human SP-D, comprising the homotrimeric neck and the carbohydrate recognition domain region, able to reach distal lung locations due to its smaller size and higher resistance to proteases and collagenases compared to the full size SP-D, appear to contribute to significant inhibition of infectivity and replication of SARS-CoV-2 present in the clinical samples derived from patients with asymptomatic, symptomatic, and severe COVID-19 (69). The gene discussed is SFTPD; the disease is COVID-19.