SARS-CoV-2 promotes inflammation and could potentiate or accelerate the pre-existing systemic inflammatory state of individuals with obesity, diabetes, hypertension and other inflammatory diseases, through NOD-like receptor (NLR) family pyrin domain-containing 3 (NLRP3) inflammasome activation via cleavage and activation of key inflammatory molecules including active caspase-1 (Casp1p20), interleukin (IL)-1β, and IL-18 and cell release of those pro-inflammatory cytokines through Gasdermin D pores commonly found in cell death by pyroptosis (45–54). The gene discussed is NLRP3; the disease is obesity disorder.