TAC3 and central precocious puberty: Additionally, in the cohort of CPP patients under investigation, a number of other more frequent variants in a series of genes (KISS1R, TAC3, GNRH1, GNRHR, LHCGR, MAGEL2, and FSHR) also directly or indirectly involved in pubertal control and activation have been observed (Supplementary Table S2).