Additionally, in the cohort of CPP patients under investigation, a number of other more frequent variants in a series of genes (KISS1R, TAC3, GNRH1, GNRHR, LHCGR, MAGEL2, and FSHR) also directly or indirectly involved in pubertal control and activation have been observed (Supplementary Table S2). The gene discussed is GNRH1; the disease is central precocious puberty.