Additionally, in the cohort of CPP patients under investigation, a number of other more frequent variants in a series of genes (KISS1R, TAC3, GNRH1, GNRHR, LHCGR, MAGEL2, and FSHR) also directly or indirectly involved in pubertal control and activation have been observed (Supplementary Table S2). This evidence concerns the gene KISS1R and central precocious puberty.