Supplementary Table 2 showed the clinical characteristics and biochemical index of all the participants in this study. For CAD vs. HCs in cohort 1, age, sex, BMI, DBP, ALT, AST, TC, eGFR, and CR were comparable among the two populations (p > 0.05). However, compared with HCs, individuals with CAD had higher SBP, HbA1c, FPG, TG, and LDL-C, but lower HDL-C levels. Similarly, for MetS vs. HCs in cohort 2, MetS patients had higher SBP, HbA1c, FPG, TC, TG, and LDL-C, but lower levels of HDL-C. The gene discussed is GPT; the disease is metabolic syndrome.