PLA2G7 and Stroke: In 1,946 participants of the Northern Manhattan study, there was a dose-response relationship between Lp-PLA2 mass and the risk of first-ever stroke due to large vessel atherosclerosis (HR = 1.4, 4.5, and 5.1 for quartiles 2, 3, and 4 compared with quartile 1 in multivariable survival analysis).