TARDBP and amyotrophic lateral sclerosis: In most patients the cause of ALS is unknown or sporadic (sALS), although some inherit familiar forms of the disease (fALS), associated with several alterations in genes (4), such as superoxide dismutase 1 (SOD1) (5), hexanucleotide repeat expansions in chromosome 9 open reading frame 72 (C9orf72) (6, 7), TAR-DNA binding protein (TDP-43) (8, 9), and DNAJC7 (10).