Available data suggested that experiences of abuse, neglect, and bully victimization in childhood, temperamental traits of impulsive aggression and negative affectivity interacting with dysfunctional familial environment, volumetric and functional abnormalities in fronto-limbic areas associated to precocious trauma and specific polymorphisms of genes (MAOA; 5-HTTLPR; FKBP5; CRHR2; 5HTTR; COMT) characterize subjects at high risk to develop BPD. This evidence concerns the gene COMT and Borderline personality disorder.