Cx43 is also involved in the human disease oculodentodigital dysplasia (ODDD; Paznekas et al., 2003, 2009; Laird, 2014), a disorder characterized by congenital missing teeth, microdontia, enamel hypoplasia, syndactyly, osteodysplasia, and craniofacial deformities (Judisch et al., 1979; Paznekas et al., 2003). This evidence concerns the gene GJA1 and oculodentodigital dysplasia.