GJA1 and heart failure: This role of Cx43 hemichannel-mediated calcium entry in PKP2-cKO arrhythmogenesis is also consistent with recent studies showing its pro-arrhythmic effect (van Opbergen et al., 2019), and has been reported in other conditions such as heart failure (Smet et al., 2021) and muscular dystrophy (Patrick Gonzalez et al., 2015).