This role of Cx43 hemichannel-mediated calcium entry in PKP2-cKO arrhythmogenesis is also consistent with recent studies showing its pro-arrhythmic effect (van Opbergen et al., 2019), and has been reported in other conditions such as heart failure (Smet et al., 2021) and muscular dystrophy (Patrick Gonzalez et al., 2015). Here, GJA1 is linked to muscular dystrophy.