The marker was identified using a proteomic based analysis of urinary E-cadherin of patients having type 2 diabetes with normo-albuminuria microalbuminuria, macroalbuminuria and is upregulated 1.3-, 5.2-, and 8.5-folds, respectively as compared to control group (Jiang et al., 2009). The gene discussed is CDH1; the disease is type 2 diabetes mellitus.