DNMT1 and diabetic kidney disease: The expression of the DNA repair factor lysine acetyltransferase 5 (KAT5) was reduced in the glomeruli of diabetic nephropathy in mouse models and humans, and knockdown of podocyte KAT5 expression caused focal segmental glomerulosclerosis with increased DNA DSBs and increased DNMT1 and DNMT3B expression with phenotypical changes in podocytes.