Liu et al. found that Treg infiltrated densely in gliomas induced the expression of stemness related genes CD133, SOX2, NESTIN and so on, activated GSCs and promoted tumor growth by secreting TGF-β mediated NF-κB-IL6-STAT3 signaling pathway (Liu et al., 2021). The gene discussed is TGFB1; the disease is glioma.