Polymethoxylated flavonoids, such as sinensetin, have been widely reported with anti-inflammatory, anti-oxidant, anti-dementia, and vasorelaxant activities and the action mechanisms could be involved in the regulation of different targets and signaling pathways including AKT and NF-κB signaling pathways (Lee et al., 2020). The gene discussed is NFKB1; the disease is dementia.