F. Zengerling et al. reported that inhibition of IGF-1R resulted in a down-regulation of AR, Q641X and AR-V7 signaling in PCa cells (Zengerling et al., 2016), which suggests that IGF-1/IGF-1R axis is a modulator of the AR△LBD signaling, providing a rationale by targeting growth factor receptor for CRPC treatment. The gene discussed is AR; the disease is posterior cortical atrophy.