Almost all these candidates show anti-prostate cancer activities via anti-proliferation, apoptosis induction or metastasis and invasion inhibition, involved in canonical AR signaling and non-AR signaling like caspase cascades, AKT/mTOR pathway, MAPKs pathway, NF-κB pathway, Ca2+ pathway and JAK/STATs pathway. This evidence concerns the gene AKT1 and prostate cancer.