The use of cholesterol for de novo steroidogenesis requires the components of the steroidogenic machinery present in the adrenals and gonads, including steroidogenic acute regulatory proteins, CYP11A1 and CYP17A1 (Miller and Auchus, 2011), which may play important roles in prostate cancer (Locke et al., 2008). Here, CYP17A1 is linked to Familial prostate cancer.