Another study showed that by inducing TIMP-2 expression and decreasing TGF-1, Wogonin inhibited the activity of MMP-2, APN and EGFR-TPK, activated caspase 3, and played an important role in the metastasis and apoptosis of lung cancer A549 cells (Chengyang and Chuangcheng, 2019). This evidence concerns the gene CASP3 and lung cancer.