CASP3 and lung carcinoma: Another study showed that by inducing TIMP-2 expression and decreasing TGF-1, Wogonin inhibited the activity of MMP-2, APN and EGFR-TPK, activated caspase 3, and played an important role in the metastasis and apoptosis of lung cancer A549 cells (Chengyang and Chuangcheng, 2019).