Therefore, this study used cytokines antibody array to explore the changes of cytokines in serum of allergic asthma mice, and finally screened out 18 differential expression proteins in serum of allergic asthma mice, which were OPG, Fractalkine, Tryptase ε, IL-25, CCL19, MCP-1, OX40L, Axl, CCL22, CD30, G-CSF, VEGF, E-selectin, OPN, CCL5, P-selectin, Gas6, TSLP. This evidence concerns the gene TNFRSF8 and allergic asthma.