The interaction between cytokines and cells can transmit signals between cells in asthma, and participate in a variety of biological processes, including inflammatory cell recruitment, airway remodeling, Th2 cell polarization, IgE synthesis, mast cell degranulation, etc. These cytokines driven effects are used to connect the complex network of cell-cell interactions in asthma (Lambrecht et al., 2019). The gene discussed is IGHE; the disease is asthma.