Among them, MCP-1, G-CSF (Kato et al., 2010), CD30 (Lombardi et al., 2010), CCL5 (Hamsten et al., 2016), E-selectin (Bi et al., 2018), P-selectin (Johansson et al., 2020), OPN (Xu et al., 2019) have been repeatedly reported as biomarkers of allergic asthma, which were highly expressed in the serum of patients. Here, SPP1 is linked to allergic asthma.