Therefore, this study used cytokines antibody array to explore the changes of cytokines in serum of allergic asthma mice, and finally screened out 18 differential expression proteins in serum of allergic asthma mice, which were OPG, Fractalkine, Tryptase ε, IL-25, CCL19, MCP-1, OX40L, Axl, CCL22, CD30, G-CSF, VEGF, E-selectin, OPN, CCL5, P-selectin, Gas6, TSLP. The gene discussed is IL25; the disease is allergic asthma.