However, in islet tissue, which plays an important role in T2DM, it is not clear how the regulatory relationship between miR-204 and SIRT1 is; moreover, whether the increase in miR-204 in the diabetic state occurs through the influence of SIRT1 expression to participate in β-cell functional damage is also unclear. The gene discussed is SIRT1; the disease is type 2 diabetes mellitus.