The role of Kv1.3 channels in MS is further strengthened by reports showing that Kv1.3-selective blockers (Beeton et al., 2001; Beeton et al., 2006) and genetic knockout of Kv1.3 (Gocke et al., 2012), ameliorate disease in animal models of multiple sclerosis. This evidence concerns the gene KCNA3 and myeloid sarcoma.