TGFB1 and neoplasm: TGF-β, which is called transforming growth factor due to its role in cell transformation, not only participates in the EMT process of embryonic development (Mercado-Pimentel and Runyan, 2007), but also regulates tumor EMT process (Derynck and Zhang, 2003; Peinado et al., 2003; Micalizzi et al., 2009).