In the CCl4-induced liver fibrosis rat experiment, qPCR showed that the mRNA expressions of Jagged1, Jagged2, Notch2, Notch3, Notch4 and recombination signal binding protein-κB (RBP-κB) were significantly more upregulated in the CCl4 group than those in the control group. Here, NOTCH4 is linked to Hepatic fibrosis.