TIPE2 and gastric neoplasm: MTT assay showed that polyphyllin I, gracillin, and dioscin exhibited lower cellular proliferation ratio (lower than 60 versus 100% of the control group, Figure 2A), meanwhile, immunoblotting indicated that gracillin had an obvious induction of TIPE2 expression in BGC823 cells (Figure 2B), demonstrating that gracillin could be a TIPE2 inducer suppressing gastric tumor cell proliferation.