MAPT and Alzheimer disease: It has been well-established that hallmarks of AD-related pathological proteins, including amyloid-β (Aβ) oligomers and hyperphosphorylated tau, disrupt normal neuronal functions in the brain, leading to unbalanced neuronal excitatory-inhibitory tone, distorted neuronal synchrony, and network oscillations (Mucke and Selkoe, 2012; Das et al., 2018).