APP and Alzheimer disease: Sirtuins play important role in maintaining neuronal health during aging (Herskovits and Guarente, 2014) and accumulating evidence demonstrates that Sirts regulate multiple processes associated with the pathogenesis of AD, such as APP processing, tau aggregation, mitochondrial dysfunction, oxidative stress, and neuroinflammation (Lalla and Donmez, 2013; Jęśko et al., 2017; Lee et al., 2018; Mohamad Nasir et al., 2018; Rizzi and Roriz-Cruz, 2018).