Since we found a decrease of NA in the prefrontal cortex after nepicastat treatment compared to vehicle-treated PTSD mice, the DBH inhibitor nepicastat may reduce NA levels in prefrontal cortex contributing to prefrontal cortex noradrenergic hyporesponsiveness and decrease PTSD traumatic contextual memories and anxiety-like behavior. The gene discussed is DBH; the disease is post-traumatic stress disorder.