Hippocampus mRNA expression of neuronal PAS domain protein (Npas4, t(10) = 3.77, p = 0.0044; Cohen’s d = 2.63; Figure 8A) and brain-derived neurotrophic factor (Bdnf, t(10) = 2.33, p = 0.0450; Cohen’s d = 1.61; Figure 8B) were significantly increased in mice in the PTSD-group and treated with nepicastat when compared to mice treated with vehicle. The gene discussed is NPAS4; the disease is post-traumatic stress disorder.