PGAM5 and cancer: The release of cleaved PGAM5 from mitochondria allows PGAM5 to interact with and dephosphorylate its candidate substrates in cytosol (Sekine et al., 2012; Bernkopf et al., 2018), such as β-catenin to activate WNT canonical signaling in cancer cells (Bernkopf et al., 2018).