Very recently, heterozygous mutations in STUB1 have been reported to cause dominant spinocerebellar ataxia type 48 (SCA48) (Ravel et al., 2021), which is characterized by a later age of onset and a wide range of variably associated phenotypes including parkinsonism, cognitive-psychiatric disorder, chorea, epilepsy, and endocrine dysfunctions (De Michele et al., 2020). This evidence concerns the gene STUB1 and Parkinson disease.