Moreover, mutations of CHIP causing inability to target protein substrates result in the formation of protein aggregates, and have been associated with the development of many neurodegenerative disorders including Alzheimer’s (Dickey et al., 2006), Parkinson’s (Tetzlaff et al., 2008), and polyglutamine diseases (Jana et al., 2005; Williams et al., 2009). Here, STUB1 is linked to Parkinsonism.