STUB1 and heart disorder: In addition, CHIP is involved in many signaling pathways and dysregulation of CHIP function has been implicated in several human diseases including cancers (Cheng et al., 2018; Tang et al., 2019), cardiac diseases (Naito et al., 2010; Cao et al., 2016), and other stress-related pathologies (Joshi et al., 2016).