Furthermore, LIM domain kinases (LIMKs), such as LIM domain kinases 1 and 2 (Limk1/2), and mediated cAMP response element-binding (CREB) protein phosphorylation induced the transcription of genes critical to long-term potentiation (LTP) and memory, while Limk1/2 deficiency led to delayed LTP and memory impairment, indicating that LIMKs play an important role in synaptic maturation and consolidation of synaptic plasticity (Meng et al., 2004). The gene discussed is CREB1; the disease is memory impairment.