LIMK1 and memory impairment: Furthermore, LIM domain kinases (LIMKs), such as LIM domain kinases 1 and 2 (Limk1/2), and mediated cAMP response element-binding (CREB) protein phosphorylation induced the transcription of genes critical to long-term potentiation (LTP) and memory, while Limk1/2 deficiency led to delayed LTP and memory impairment, indicating that LIMKs play an important role in synaptic maturation and consolidation of synaptic plasticity (Meng et al., 2004).