TREM2 and Alzheimer disease: Interestingly, DAM express some AD risk genes such as Apoe (Corder et al., 1993), Ctsd (Paz et al., 2015), Tyrobp (Pottier et al., 2016), and Trem2 (Guerreiro et al., 2013; Keren-Shaul et al., 2017).