PRKN and Parkinson disease: Mutations in PD-associated genes encoding for the PTEN-induced kinase 1 (PINK1, PARK6), Parkin (PRKN, PARK2), and protein deglycase (DJ-1, PARK7) proteins cause autosomal recessive PD and are involved in mitochondrial homeostasis and mitophagy (Abou-Sleiman et al., 2004; Trempe et al., 2013).