COMT and Parkinsonism: Classical parkinsonism is typically characterized by an excellent and sustained therapeutic response to levodopa (L-dopa) (Carlsson et al., 1957), while other medications, such as dopamine agonists, monoamine oxidase-B (MAO-B) inhibitors, and catechol-O-methyltransferase (COMT) inhibitors are also commonly used in the clinical practice (Armstrong and Okun, 2020).