Importantly, the mislocalization of RBPs, such as TDP-43, FUS and hnRNP A1, is a histopathological feature of several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) (Deshaies et al., 2018; Aksoy et al., 2020; de Boer et al., 2020). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.